circRNA basic information
circBase ID: hsa_circ_0026134
Name: hsa_circ_TUBA1C
Synonym: circ_0026134
Host Gene: TUBA1C
Genomic location(hg19): chr12:49658864-49667113:+
Genomic location(hg38): chr12:49265081-49273330:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissue specimens; NSCLC tissues; adjacent non-cancerous tissue samples
Cell lines:

16HBE; H1299; H1581; H358; A549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TCTN1, GAGE1
Associated microRNA: miR-1256, miR-1287
Biological function: promotes cell proliferation, migration and invasion; inhibits apoptosis
Molecular mechanism: ceRNA mechanism by sponging miR-1256 and miR-1287
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis
Clinical significance:

This study may provide a new insight and treatment target for NSCLC.
Description:

circ_0026134 is upregulated in NSCLC and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion and cell survival while inhibiting apoptosis, mainly by sponging miR-1256 and miR-1287 and thereby regulating downstream targets such as TCTN1 and GAGE1.
Confidence score:

0.5554
Other information
Title:

Circular RNA circ_0026134 regulates non-small cell lung cancer cell proliferation and invasion via sponging miR-1256 and miR-1287.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: 2019
PubMed ID: 30970529
Study type:

biological research
Data availability: -
Code availability: -