| Expression pattern: |
UP |
| Associated gene: |
VAMP2, MDM2 |
| Associated microRNA: |
miR-646, miR-647 |
| Biological function: |
Promotes OC cell proliferation, migration and invasion, and inhibits apoptosis; associated with clinical severity and adverse prognosis. |
| Molecular mechanism: |
circ-FAM53B functions as a ceRNA that sponges miR-646 and miR-647, thereby upregulating VAMP2 and MDM2 expression at the post-transcriptional level. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Cohort Study; Survival Analysis |
| Clinical significance: |
High circ-FAM53B expression correlates with tumor size, FIGO stage, lymph node invasion, poor survival, and can be regarded as an independent prognostic indicator. |
| Description: |
circ-FAM53B is upregulated in ovarian cancer tissues and cell lines and is associated with clinical severity and poor prognosis. Functionally, it promotes proliferation, migration and invasion while suppressing apoptosis in OC cells. Mechanistically, cytoplasmic circ-FAM53B acts as a ceRNA for miR-646 and miR-647, increasing VAMP2 and MDM2 expression to drive OC progression. |
| Confidence score: |
0.7628 |