circRNA basic information
circBase ID: hsa_circ_0001806
Name: hsa_circ_CSPP1
Synonym: circ-CSPP1
Host Gene: CSPP1
Genomic location(hg19): chr8:68018139-68028357:+
Genomic location(hg38): chr8:67105904-67116122:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer / OC
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

normal ovarian tissues; benign tumors; borderline tumors; EOC tissues; ovarian carcinomas
Cell lines:

CAOV3; A2780; OVCAR3; HEK293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ZEB1, E-cadherin, N-cadherin, MMP-2, VEGFA
Associated microRNA: miR-1236-3p
Biological function: circ-CSPP1 promotes ovarian cancer cell growth, proliferation, migration, invasion, EMT and ovarian cancer development.
Molecular mechanism: circ-CSPP1 acts as a miR-1236-3p sponge, attenuates the inhibitory effect of miR-1236-3p on ZEB1, and thereby promotes EMT and ovarian cancer development.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Wound Healing Assay; Transwell Assay; Western Blot
Clinical significance:

circ-CSPP1 expression was positively correlated with FIGO staging and differentiation, and the findings provide a new perspective for early diagnosis and targeted therapy of ovarian cancer.
Description:

circ-CSPP1 (hsa_circ_0001806), derived from CSPP1, is up-regulated in ovarian cancer tissues and higher expression correlates with more advanced FIGO stage and poorer differentiation. Functionally, it promotes ovarian cancer cell growth, migration and invasion by sponging miR-1236-3p, relieving miR-1236-3p-mediated inhibition of ZEB1 and promoting EMT-related changes.
Confidence score:

0.6815
Other information
Title:

circ-CSPP1 promotes proliferation, invasion and migration of ovarian cancer cells by acting as a miR-1236-3p sponge.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: 2019
PubMed ID: 30965236
Study type:

combined biological and clinical study
Data availability: All data generated or analysed during this study are included in this published article; Supplementary material related to this article can be found, in the online version, at doi:https://doi.org/10.1016/j.biopha.2019.108832
Code availability: -