| Expression pattern: |
UP |
| Associated gene: |
PPDPF, MACC1 |
| Associated microRNA: |
miR-1304-5p |
| Biological function: |
circ-FOXM1 promotes NSCLC cell growth, migration and invasion, and inhibits apoptosis. |
| Molecular mechanism: |
circ-FOXM1 acts as a ceRNA by sponging miR-1304-5p to upregulate PPDPF and MACC1 at the post-transcriptional level. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ-FOXM1 overexpression is associated with lymph node invasion, higher TNM stage and unfavorable prognosis; high circ-FOXM1 expression is an independent prognostic indicator in NSCLC. |
| Description: |
circ-FOXM1 is up-regulated in NSCLC tissues and cell lines and is associated with advanced TNM stage, lymph node metastasis and poorer survival. Functionally, circ-FOXM1 promotes NSCLC cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-1304-5p to increase PPDPF and MACC1 expression. |
| Confidence score: |
0.7408 |