circRNA basic information
circBase ID: hsa_circ_0051240
Name: hsa_circ_CEACAM5
Synonym: circ_0051240
Host Gene: CEACAM5
Genomic location(hg19): chr19:42224841-42231272:+
Genomic location(hg38): chr19:41720921-41727352:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer / OC
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

OC tissues; adjacent normal tissues; corresponding adjacent non-cancerous tissues
Cell lines:

CAOV-3; SKOV-3; OVCAR-3; H8910; HOSE
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: KLK4 mRNA, KLK4
Associated microRNA: miR-637
Biological function: Promotes OC cell proliferation, colony formation, migration, invasion, and tumour formation in vivo; silencing hsa_circ_0051240 inhibits these malignant phenotypes.
Molecular mechanism: hsa_circ_0051240 functions as a miR-637 sponge, thereby relieving miR-637-mediated suppression of KLK4 and promoting OC progression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
M
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Microarray; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Cohort Study; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High hsa_circ_0051240 expression is correlated with lymph node metastasis, FIGO stage, CA125 level, metastasis, and poor prognosis; it may act as a potential biomarker and therapeutic target for OC.
Description:

hsa_circ_0051240 is up-regulated in ovarian cancer tissues and cell lines and is associated with metastasis-related clinicopathologic features and poor survival. Functionally, it promotes OC proliferation, colony formation, migration, invasion, and xenograft tumour growth. Mechanistically, it acts as a ceRNA sponge for miR-637 to regulate KLK4 expression, forming the hsa_circ_0051240/miR-637/KLK4 axis.
Confidence score:

0.8703
Other information
Title:

Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis.

Journal: Artificial cells, nanomedicine, and biotechnology
Published: 2019
PubMed ID: 30945557
Study type:

combined biological and clinical study
Data availability: -
Code availability: -