| Expression pattern: |
UP |
| Associated gene: |
ATP-binding cassette super-family G member 2 / ABCG2 |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
circCEP128 promotes glioma cell proliferation and temozolomide resistance; knockdown suppresses proliferation, decreases ABCG2 expression, and improves the cytotoxic efficacy of temozolomide. |
| Molecular mechanism: |
circCEP128 functions as a sponge for miR-145-5p and regulates glioma cell proliferation and temozolomide resistance partly through ABCG2. |
| Biological pathway or process: |
proliferation (promotes); chemoresistance (promotes); drug resistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circCEP128 might be a promising therapeutic target for overcoming temozolomide resistance in glioma. |
| Description: |
circCEP128 is up-regulated in glioma tissues, glioma cell lines, and TMZ-resistant glioma cells. Functionally, circCEP128 promotes glioma cell proliferation and temozolomide resistance, while its knockdown suppresses proliferation and enhances TMZ cytotoxicity. Mechanistically, circCEP128 acts as a miR-145-5p sponge and regulates ABCG2 expression, suggesting therapeutic potential for overcoming TMZ resistance. |
| Confidence score: |
0.6996 |