| Expression pattern: |
UP |
| Associated gene: |
DDR2 / discoidin domain receptor tyrosine kinase 2 |
| Associated microRNA: |
miR-615-5p |
| Biological function: |
Promotes T-LBL cell proliferation and cell growth, inhibits cell apoptosis, and acts as an oncogene in T-LBL. |
| Molecular mechanism: |
circ-LAMP1 acts as a ceRNA by sponging miR-615-5p, thereby regulating DDR2 expression through the miR-615-5p/DDR2 signaling axis. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
circ-LAMP1 might be useful in developing promising therapies for T-LBL; the prognostic role was not investigated. |
| Description: |
circ-LAMP1/hsa_circRNA_101303 is upregulated in T-LBL tissues and cell lines. It promotes T-LBL cell proliferation and inhibits apoptosis by acting as a ceRNA for miR-615-5p, thereby increasing DDR2 expression through the circ-LAMP1/miR-615-5p/DDR2 axis. The study suggests circ-LAMP1 may be an oncogenic therapeutic target in T-LBL, while its prognostic value was not investigated. |
| Confidence score: |
0.6777 |