circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): chr11:33307958-33309057:+
Genomic location(hg38): chr11:33286412-33287511:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005010
MONDO name: coronary artery disorder
Disease details: coronary heart disease
Disease DO ID:
 3393
Disease MeSH ID:
 D003324
Disease NCIt ID:
 C26732
Disease ICD11 ID:
 1059873720
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

whole blood; peripheral blood leukocytes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with increased CHD risk; discussed as related to vascular endothelial cell growth/proliferation and plaque rupture (contextual evidence cited).
Molecular mechanism: Not specified for CHD in this study.
Biological pathway or process:

proliferation (other); migration (other); angiogenesis (other); inflammation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study
Clinical significance:

AUC=0.68 for diagnosing CHD; high expression is an independent risk factor for CHD.
Description:

hsa_circ_0000284 (circHIPK3) is up-regulated in CHD peripheral blood leukocytes and is an independent risk factor with diagnostic value (AUC 0.68). The study does not establish a CHD-specific molecular mechanism, but discusses circHIPK3 in relation to endothelial cell proliferation/migration and vascular dysfunction based on prior evidence.
Confidence score:

0.5202
Other information
Title:

Association of circular RNAs and environmental risk factors with coronary heart disease.

Journal: BMC cardiovascular disorders
Published: 2019
PubMed ID: 31619168
Study type:

combined biological and clinical study
Data availability: The datasets generated and/or analysed during the current study are not publicly available due the principle of confidentiality of funding but are available from the corresponding author on reasonable request.
Code availability: -