| Expression pattern: |
DN |
| Associated gene: |
IL-7R, IL-18, TNFSF14, CD28 |
| Associated microRNA: |
miR-200a-3p |
| Biological function: |
circPTPN22 may serve as a diagnostic biomarker and disease severity/activity indicator for SLE, with lower expression associated with higher SLEDAI scores and increased expression after hormone treatment. |
| Molecular mechanism: |
Bioinformatics-based circRNA-miRNA-mRNA coexpression network suggests that circPTPN22 may function through a circRNA-miRNA sponge mechanism involving immunological regulatory processes. |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Sanger Sequencing; RT-qPCR; RNA-seq; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circPTPN22 is negatively correlated with SLEDAI score, reflects disease status and response to hormone therapy, and has diagnostic value for SLE with ROC AUC 0.918. |
| Description: |
circPTPN22 is a previously undescribed human circRNA derived from PTPN22 and is down-regulated in PBMCs from patients with SLE. Its expression is negatively associated with SLE disease activity, increases after hormone treatment, and shows diagnostic potential; bioinformatics suggests a circPTPN22-miRNA-mRNA immune regulatory network. |
| Confidence score: |
0.5963 |