| Expression pattern: |
UP |
| Associated gene: |
CXCR4 |
| Associated microRNA: |
miR-186-5p, miR-548c-3p |
| Biological function: |
Promotes proliferation, migration, invasion, EMT, tumor growth and lung metastasis in TNBC. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-186-5p and miR-548c-3p to derepress CXCR4 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
High circBACH2 expression is positively correlated with malignant progression (T stage, N stage, TNM stage) of TNBC patients. |
| Description: |
circBACH2 is up-regulated in TNBC tissues/cell lines and promotes proliferation, migration, invasion, EMT, and in vivo tumor growth and lung metastasis. It functions as a ceRNA by sponging miR-186-5p and miR-548c-3p to increase CXCR4 expression, forming a circBACH2-miR-186-5p/miR-548c-3p-CXCR4 axis associated with malignant progression. |
| Confidence score: |
0.742 |