| Expression pattern: |
UP |
| Associated gene: |
HMGA2, Ago2 |
| Associated microRNA: |
miR-330-5p |
| Biological function: |
promotes NSCLC cell proliferation and inhibits apoptosis |
| Molecular mechanism: |
circ_0001666 acts as a sponge for miR-330-5p and indirectly up-regulates HMGA2 through the miR-330-5p/HMGA2 axis |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Nuclear-Cytoplasmic Fractionation; Western Blot |
| Clinical significance: |
circ_0001666 may serve as a biomarker for early diagnosis and treatment of NSCLC and is expected to be a prognostic biomarker and new therapeutic target |
| Description: |
circ_0001666 is up-regulated in NSCLC tissues and cell lines. It promotes NSCLC cell proliferation and inhibits apoptosis by sponging miR-330-5p and indirectly up-regulating HMGA2, suggesting potential value as a biomarker and therapeutic target. |
| Confidence score: |
0.6956 |