circRNA basic information
circBase ID: -
Name: hsa_circ_ERBB2
Synonym: circ-ERBB2
Host Gene: ERBB2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissue specimens; adjacent noncancerous tissue samples
Cell lines:

AGS; BGC823; MGC803; SGC7901; GES1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CACUL1, MMP-19
Associated microRNA: miR-503, miR-637
Biological function: circ-ERBB2 functions as an oncogene in gastric cancer, promoting cell proliferation, clonogenic ability, migration, invasion, tumor growth and invasive potential, while inhibiting apoptosis.
Molecular mechanism: circ-ERBB2 acts as a miRNA sponge for miR-503 and miR-637, thereby regulating CACUL1 and MMP-19 expression and promoting tumor growth and invasion via miR-503/CACUL1 and miR-637/MMP-19 pathways.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; Survival Analysis; Bioinformatics Analysis; Cohort Study
Clinical significance:

circ-ERBB2 upregulation was associated with tumor size, depth of invasion, TNM stage and poorer overall survival in gastric cancer patients.
Description:

circ-ERBB2 is up-regulated in gastric cancer tissues and cell lines, and high expression is associated with aggressive clinicopathological features and poor overall survival. Functionally, circ-ERBB2 promotes gastric cancer cell proliferation, migration and invasion and suppresses apoptosis. Mechanistically, it acts as a miRNA sponge for miR-503 and miR-637 to regulate CACUL1 and MMP-19 signaling.
Confidence score:

0.7408
Other information
Title:

Upregulation of circular RNA circ-ERBB2 predicts unfavorable prognosis and facilitates the progression of gastric cancer via miR-503/CACUL1 and miR-637/MMP-19 signaling.

Journal: Biochemical and biophysical research communications
Published: 2019
PubMed ID: 30853181
Study type:

combined biological and clinical study
Data availability: -
Code availability: -