| Expression pattern: |
UP |
| Associated gene: |
CKS2, TOP2A, PARP1, UHRF1, GINS1 |
| Associated microRNA: |
miR-7-5p |
| Biological function: |
Curcumin-associated downregulation of hsa_circ_0001946 suppresses proliferation and migration and promotes apoptosis in breast cancer cells. |
| Molecular mechanism: |
hsa_circ_0001946 acts as a miRNA sponge for miR-7-5p to regulate oncogenic target genes (e.g., CKS2, TOP2A, PARP1, UHRF1, GINS1); curcumin suppresses this axis by downregulating hsa_circ_0001946 and increasing miR-7-5p. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
The hsa_circ_0001946/miR-7-5p/CKS2 axis is proposed as a potential biomarker for breast cancer. |
| Description: |
hsa_circ_0001946 (CDR1as/ciRS-7) is upregulated in breast cancer tissues and cell lines and functions as a sponge for miR-7-5p to support oncogenic target gene expression (e.g., CKS2). Curcumin suppresses breast cancer cell proliferation and migration and promotes apoptosis partly by downregulating hsa_circ_0001946 and restoring miR-7-5p, thereby reducing downstream oncogenic targets. |
| Confidence score: |
0.5732 |