| Expression pattern: |
UP |
| Associated gene: |
AGR2 |
| Associated microRNA: |
miR-217 |
| Biological function: |
promotes cervical cancer cell proliferation, migration, adhesion, tumor formation and tumor growth |
| Molecular mechanism: |
circ_0119412 acts as a ceRNA by targeting/sequestering miR-217 to relieve miR-217-mediated inhibition of AGR2, thereby upregulating AGR2 and promoting cervical cancer progression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; MTT; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
targeted inhibition of circ_0119412 might be a therapeutic strategy for cervical cancer |
| Description: |
hsa_circ_0119412/circ_0119412 is up-regulated in cervical cancer tissues and cell lines. It promotes cervical cancer cell proliferation, migration, adhesion and xenograft tumor growth by sequestering miR-217 and relieving inhibition of AGR2. The study suggests that targeting circ_0119412 may have therapeutic potential in cervical cancer. |
| Confidence score: |
0.7795 |