| Expression pattern: |
UP |
| Associated gene: |
CNBP |
| Associated microRNA: |
miR-330-3p |
| Biological function: |
circPACRGL promotes CRC cell proliferation, migration, invasion and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circPACRGL functions as a ceRNA/miRNA sponge for miR-330-3p to upregulate CNBP expression, thereby promoting CRC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; IHC (Immunohistochemistry); Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circPACRGL is highlighted as a potential therapeutic target for colorectal cancer. |
| Description: |
circPACRGL is up-regulated in colorectal cancer tissues and cells. It promotes CRC proliferation, migration, invasion and in vivo tumor growth while suppressing apoptosis, mainly by sponging miR-330-3p to increase CNBP expression. The study suggests circPACRGL may serve as a potential therapeutic target for colorectal cancer. |
| Confidence score: |
0.8299 |