| Expression pattern: |
DS |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b-5p, hsa-miR-449c-5p |
| Biological function: |
Serves as a potential biomarker for early GC screening and prognostic estimation; low tissue levels are associated with gastric carcinogenesis initiation/development; circulating levels increase in EGC and are actively secreted by cells. |
| Molecular mechanism: |
Predicted miRNA sponge (harbors miRNA seed sequences) with downstream GO/KEGG functional implications; exosome-associated secretion into plasma. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; Bioinformatics Analysis; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study |
| Clinical significance: |
Tissue hsa_circ_0086720 was negatively associated with perineural invasion and Borrmann type; plasma hsa_circ_0086720 showed diagnostic value for EGC (AUC 0.771); expression groups were associated with OS and DFS. |
| Description: |
This study reports hsa_circ_0086720 as dysregulated in gastric carcinogenesis: decreased in GC/EGC tissues but increased in EGC plasma. It supports clinical utility as a plasma biomarker for early GC screening (ROC AUC 0.771) and indicates prognostic relevance via OS/DFS stratification. Mechanistically, it is predicted to interact with miR-34c-5p and the miR-449 family and may be secreted into plasma via exosomes. |
| Confidence score: |
0.6522 |