circRNA basic information
circBase ID: hsa_circ_0121124
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC samples; tumor specimens; GC and adjacent non-tumor mucosal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: Component of a 5-circRNA signature significantly correlated with overall survival and disease-free survival in gastric cancer; identified as a protective factor with a negative Cox coefficient.
Molecular mechanism: Concrete molecular mechanism was not clarified by biological experiments; functional enrichment suggested possible involvement of cancer-related pathways and immune processes.
Biological pathway or process:

p53 signaling (other); TGF-beta/SMAD (other); immune regulation (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Cohort Study; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Included in a 5-circRNA signature highly correlated with patient prognosis; negative coefficient identified it as a protective factor.
Description:

hsa_circ_0121124 was identified from reannotated microarray data as a differentially expressed circRNA significantly correlated with overall survival in gastric cancer. It was the protective-factor component of the 5-circRNA prognostic signature, but it was not individually validated by RT-qPCR in clinical tissues.
Confidence score:

0.459
Other information
Title:

Detection of a 5-circRNA signature to improve prognostic prediction in gastric cancer.

Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research
Published: 2020
PubMed ID: 31672718
Study type:

bioinformatics and clinical prognostic study
Data availability: GSE79973; GSE62254; GSE15459
Code availability: -