| Expression pattern: |
UP |
| Associated gene: |
CCND2 |
| Associated microRNA: |
miR-627-5p |
| Biological function: |
Promotes CRC cell proliferation, invasion, migration and Warburg effect/glycolysis, and inhibits apoptosis. |
| Molecular mechanism: |
CircPDK1 acts as a ceRNA by competitively adsorbing miR-627-5p to mediate CCND2 expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
circPDK1 is correlated with TNM stage and tumor size in CRC patients and may be a valuable marker for early clinical diagnosis of CRC. |
| Description: |
hsa_circ_0057104/circPDK1 is up-regulated in colorectal cancer tissues and cell lines. It promotes CRC malignant phenotypes, including proliferation, invasion, migration and Warburg effect/glycolysis, while suppressing apoptosis. Mechanistically, circPDK1 acts through a ceRNA axis by sponging miR-627-5p to increase CCND2 expression, and its expression is associated with TNM stage and tumor size. |
| Confidence score: |
0.7936 |