| Expression pattern: |
UP |
| Associated gene: |
Cyclin D1, Axin2 |
| Associated microRNA: |
- |
| Biological function: |
Promotes CRC cell proliferation, colony formation, invasion, and tumor growth in vivo. |
| Molecular mechanism: |
hsa_circ_0031787 promotes CRC progression by activating the Wnt/beta-catenin signaling pathway and increasing Cyclin D1 and Axin2 expression. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; EdU Staining; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High hsa_circ_0031787 expression is associated with advanced TNM stage and lymph node metastasis in CRC patients, and it is proposed as a potential diagnostic and therapeutic target. |
| Description: |
hsa_circ_0031787 is up-regulated in colorectal cancer tissues and cell lines and is associated with advanced TNM stage and lymph node metastasis. Functionally, it promotes CRC cell proliferation, colony formation, invasion, and tumor growth in vivo. Mechanistically, the study indicates that hsa_circ_0031787 activates Wnt/beta-catenin signaling, with effects on Cyclin D1 and Axin2. |
| Confidence score: |
0.7795 |