| Expression pattern: |
DN |
| Associated gene: |
p53, E-cadherin, N-cadherin, Snail |
| Associated microRNA: |
miR-1228 |
| Biological function: |
inhibits cell proliferation, migration, invasion, metastasis and EMT in ovarian cancer |
| Molecular mechanism: |
circ_100395 sponges miR-1228, thereby regulating p53 and EMT markers (E-cadherin, N-cadherin, Snail). |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot |
| Clinical significance: |
low expression of circ_100395 was highly correlated with the poor outcomes; ovarian cancer patients with lower expression level of circ_100395 were more likely to have shorter overall survival time |
| Description: |
circ_100395 is down-regulated in ovarian cancer tissues and cell lines, and lower expression is associated with worse clinical outcomes. Functionally, circ_100395 suppresses ovarian cancer cell proliferation, migration/invasion and EMT by acting as a miR-1228 sponge and relieving miR-1228-mediated repression of p53. |
| Confidence score: |
0.7078 |