| Expression pattern: |
UP |
| Associated gene: |
integrin beta1, AGO 2 |
| Associated microRNA: |
miR-873-5p |
| Biological function: |
Promotes ADM resistance, proliferation, migration, invasion, metastasis and tumor growth, and inhibits apoptosis in ADM-resistant breast cancer cells. |
| Molecular mechanism: |
circ_0085495 functions as a miR-873-5p sponge to positively regulate integrin beta1 expression, thereby promoting ADM resistance and malignant phenotypes in breast cancer cells. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ_0085495 is indicated as a promising target for overcoming or reducing ADM resistance in breast cancer treatment. |
| Description: |
circ_0085495 is upregulated in ADM-resistant breast cancer cells and promotes chemoresistance, proliferation, migration, invasion and tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-873-5p, thereby increasing integrin beta1 expression. Knockdown of circ_0085495 reduces ADM resistance, suggesting potential therapeutic value in breast cancer. |
| Confidence score: |
0.7451 |