circRNA basic information
circBase ID: -
Name: hsa_circ_HMGCS1
Synonym: hsa_circRNA_103827
Host Gene: HMGCS1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 -
MONDO name: -
Disease details: aging
Disease DO ID:
 -
Disease MeSH ID:
 D000375
Disease NCIt ID:
 C16269
Disease ICD11 ID:
 -
Disease OMIM ID:
 502000
Species: Human
Species details: Homo sapiens
Tissue specimen:

granulosa cells (GCs)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ANKRD20A9P, KCNQ1OT1, XIST
Associated microRNA: hsa-miR-411-5p, hsa-miR-625-3p
Biological function: Associated with declining ovarian reserve and adverse embryo outcomes; predictive for clinical pregnancy and live birth after ART.
Molecular mechanism: Predicted miRNA sponge (ceRNA) mechanism based on bioinformatics.
Biological pathway or process:

glycolysis (other); cell cycle (other); ovarian steroidogenesis (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

circRNA_103827 expression in granulosa cells is negatively associated with top quality embryos and has ROC predictive performance for clinical pregnancy and live birth in ART cycles.
Description:

circRNA_103827 (hsa_circRNA_103827, from HMGCS1) is up-regulated in granulosa cells from older women and correlates with reduced ovarian reserve indicators (AMH, AFC) and poorer embryo outcomes. Its expression level in granulosa cells shows ROC-based predictive value for clinical pregnancy and live birth after ART, and bioinformatics suggests a potential ceRNA (miRNA sponge) role affecting targets such as ANKRD20A9P, KCNQ1OT1, and XIST, with links to glucose metabolism, mitotic cell cycle, and ovarian steroidogenesis.
Confidence score:

0.6841
Other information
Title:

Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes.

Journal: PloS one
Published: 2017
PubMed ID: 28644873
Study type:

combined biological and clinical study
Data availability: GSE97193
Code availability: -