| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-1231, miR-1304 |
| Biological function: |
circ_0025033 promotes PTC cell proliferation, clone formation, migration and invasion, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0025033 functions as a miRNA sponge for miR-1231 and miR-1304, and its oncogenic role depends on suppression of miR-1231 and miR-1304. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay |
| Clinical significance: |
This work may expedite the exploration of novel targets for the treatment of PTC. |
| Description: |
circ_0025033 is up-regulated in papillary thyroid cancer tissues and cell lines. It acts as an oncogenic circRNA that promotes proliferation, colony formation, migration and invasion while inhibiting apoptosis, mainly through sponging and suppressing miR-1231 and miR-1304. |
| Confidence score: |
0.6815 |