circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1as
Synonym: ciRS7 / circCDR1as
Host Gene: CDR1-AS
Genomic location(hg19): chrX:139865339-139866824:+
Genomic location(hg38): chrX:140783174-140784659:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004976
MONDO name: amyotrophic lateral sclerosis
Disease details: amyotrophic lateral sclerosis / ALS
Disease DO ID:
 332
Disease MeSH ID:
 D000690
Disease NCIt ID:
 C34373
Disease ICD11 ID:
 1982355687
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

spinal cord; quadriceps
Cell lines:

-
In vivo animal model:

genetically engineered animal model
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: potential biomarker (suggested)
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR
Clinical significance:

Potential biomarker of ALS or muscle damage (proposed)
Description:

ciRS7/circCDR1as decreases progressively in ALS spinal cord from early presymptomatic to terminal stages but increases in ALS quadriceps from P75 to P120; it is discussed as a potential biomarker of ALS or muscle damage.
Confidence score:

0.1155
Other information
Title:

Circular RNA expression in ALS is progressively deregulated and tissue-dependent.

Journal: BMC genomics
Published: 2025
PubMed ID: 40596818
Study type:

biological research
Data availability: -
Code availability: -