circRNA basic information
circBase ID: hsa_circ_0004674
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr7:87593948-87607727:+
Genomic location(hg38): chr7:87964633-87978412:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MG63; KHOS; U2OS; MG63/DXR; KHOS/DXR; U2OS/DXR
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Identified as the most upregulated circRNA in multi-drug chemo-resistant osteosarcoma cell lines compared with chemo-sensitive cell lines; no specific functional assay was reported for this circRNA.
Molecular mechanism: -
Biological pathway or process:

drug resistance (other); chemoresistance (other)
Detected method:
S
Validation methods:

RNA-seq
Clinical significance:

-
Description:

hsa_circ_0004674 was identified by whole-transcriptome RNA-seq as the most upregulated circRNA in chemo-resistant osteosarcoma cell lines. The article did not report RT-qPCR validation or functional/mechanistic experiments for this specific circRNA.
Confidence score:

0.1155
Other information
Title:

Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy
Published: 2019
PubMed ID: 30692017
Study type:

bioinformatics study
Data availability: Supplemental Information includes nine tables; https://doi.org/10.1016/j.ymthe.2019.01.001
Code availability: -