| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Associated with larger tumor size, microinvasion, tumor recurrence, mortality, and worse prognosis in HCC patients; proposed as a circulating exosomal prognostic biomarker. |
| Molecular mechanism: |
No specific molecular mechanism was experimentally defined; the study evaluated circulating exosomal circAKT3 as a stable exosomal circRNA biomarker associated with HCC recurrence and prognosis. |
| Biological pathway or process: |
other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
High circulating exosomal circAKT3 is associated with higher HCC recurrence, higher mortality, shorter survival time, and may serve as a predictor of clinical outcome after surgery. |
| Description: |
This study found that circulating exosomal circAKT3 is up-regulated in serum exosomes from HCC patients compared with healthy subjects. High exosomal circAKT3 is associated with larger tumors, microinvasion, higher recurrence and mortality, and poorer overall and recurrence-free survival, supporting its potential role as a non-invasive prognostic biomarker for postoperative HCC monitoring. |
| Confidence score: |
0.5727 |