| Expression pattern: |
UP |
| Associated gene: |
SLC16A3, Ago2 |
| Associated microRNA: |
miR-532-5p |
| Biological function: |
promotes proliferation, migration, invasion and glycolysis; inhibits apoptosis |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-532-5p to regulate SLC16A3. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay |
| Clinical significance: |
High serum hsa_circ_0008621 expression was associated with shorter overall survival and recurrence-free survival in CRC patients and was an independent prognostic factor. |
| Description: |
hsa_circ_0008621 is up-regulated in CRC tissues and serum and serves as a prognostic biomarker, where higher serum levels predict worse OS and RFS. Functionally, it promotes CRC cell proliferation, migration, invasion and glycolysis while inhibiting apoptosis, at least in part via a ceRNA mechanism sponging miR-532-5p to regulate SLC16A3. |
| Confidence score: |
0.7713 |