| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Promotes proliferation and invasion of NSCLC cells (oncogenic role). |
| Molecular mechanism: |
Mechanism not experimentally determined; authors suggest circATXN7 may act as a miRNA sponge. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Transfection; MTT; EdU Staining; Colony Formation Assay; Transwell Assay; Survival Analysis |
| Clinical significance: |
High circATXN7 levels were associated with shorter survival time, but not statistically significant; no significant associations with most clinicopathological characteristics. |
| Description: |
circATXN7 is upregulated in NSCLC tumor tissues. Functional knockdown experiments indicate circATXN7 promotes NSCLC cell proliferation and invasion in vitro, supporting an oncogenic role; its miRNA-sponge mechanism is proposed but not validated in this study. |
| Confidence score: |
0.7353 |