| Expression pattern: |
UP |
| Associated gene: |
YWHAZ |
| Associated microRNA: |
miR-136-5p |
| Biological function: |
promotes proliferation and invasion, inhibits apoptosis, and increases paclitaxel resistance (reduces PTX sensitivity) in PTX-resistant breast cancer cells |
| Molecular mechanism: |
circ_0069094 acts as a ceRNA to sponge miR-136-5p, thereby upregulating YWHAZ and promoting malignant phenotypes and paclitaxel resistance |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Circ_0069094 is overexpressed in paclitaxel (PTX)-resistant breast cancer tissues and is associated with PTX resistance, suggesting a potential therapeutic target. |
| Description: |
In PTX-resistant breast cancer, circ_0069094 is upregulated and promotes proliferation and invasion while inhibiting apoptosis and reducing paclitaxel sensitivity. Mechanistically, it sponges miR-136-5p to increase YWHAZ expression, forming a circ_0069094/miR-136-5p/YWHAZ axis that drives chemoresistance and malignant phenotypes. |
| Confidence score: |
0.7422 |