| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-766-5p / miR-766 |
| Biological function: |
May promote proliferation and radioresistance of normal glioma U251 cells; may serve as a potential biomarker for glioma radioresistance. |
| Molecular mechanism: |
circATP8B4 in RR-EVs may act as a miR-766-5p sponge; predicted circATP8B4-miR-766-5p-mRNA ceRNA mechanism may be involved in glioma radioresistance. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); radioresistance (promotes); drug resistance (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Bioinformatics Analysis; MTT |
| Clinical significance: |
circATP8B4 from EVs could be a potential biomarker for glioma radioresistance. |
| Description: |
circATP8B4 was up-regulated in extracellular vesicles derived from radioresistant U251 glioma cells compared with normal U251-derived EVs, and this expression change was validated by RT-qPCR. The study suggests that RR-EV-derived circATP8B4 may be transferred to recipient glioma cells and act as a miR-766-5p sponge in a predicted ceRNA mechanism, thereby promoting glioma cell radioresistance and potentially serving as a biomarker for glioma radioresistance. |
| Confidence score: |
0.4851 |