| Expression pattern: |
DN |
| Associated gene: |
CDR1, Ki67 |
| Associated microRNA: |
miR-671-5p |
| Biological function: |
Circ_0001946 inhibits GBM cell proliferation, migration, invasion, and xenograft tumor growth, and promotes apoptosis. |
| Molecular mechanism: |
Circ_0001946 acts as a competing endogenous RNA that sponges miR-671-5p, thereby upregulating CDR1 expression and suppressing GBM progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); metastasis (inhibits) |
| Detected method: |
Q
S
M
|
| Validation methods: |
RT-qPCR; RNA-seq; Microarray; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
The circ_0001946/miR-671-5p/CDR1 pathway might be a promising therapeutic target for GBM. |
| Description: |
circ_0001946 is down-regulated in GBM and functions as a tumor suppressor. It sponges miR-671-5p to increase CDR1 expression, thereby inhibiting GBM cell proliferation, migration, invasion, and xenograft tumor growth while promoting apoptosis. The circ_0001946/miR-671-5p/CDR1 axis is proposed as a potential therapeutic target for GBM. |
| Confidence score: |
0.697 |