circRNA basic information
circBase ID: hsa_circ_0071271
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr4:153253747-153259088:-
Genomic location(hg38): chr4:152332595-152337936:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; tumor tissues; para-tumorous tissues; adjacent non-tumor tissues; adjacent normal tissues
Cell lines:

A549; NCI-H292; NCI-H596; NCI-H1299; CALU-3; 16HBE
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PTEN
Associated microRNA: miR-23a-5p
Biological function: Promotes NSCLC cell proliferation, migration and invasion, and inhibits apoptosis; knockdown shows opposite effects.
Molecular mechanism: Acts via binding miR-23a-5p and regulating the miR-23a-5p/PTEN axis.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis
Clinical significance:

Shows diagnostic efficacy (ROC) and prognostic value; high expression associated with lower survival rates.
Description:

hsa_circ_0071271 is up-regulated in NSCLC tissues/cell lines and promotes malignant phenotypes (proliferation, migration/invasion) while inhibiting apoptosis. Mechanistically, it binds miR-23a-5p and functionally acts through the miR-23a-5p/PTEN axis. High hsa_circ_0071271 expression shows diagnostic value and is associated with poorer survival.
Confidence score:

0.7483
Other information
Title:

Hsa_circ_0071271 affected the progression of non-small cell lung cancer through miR-23a-5p.

Journal: Hereditas
Published: 2025
PubMed ID: 41074223
Study type:

combined biological and clinical study
Data availability: Corresponding authors may provide data and materials.
Code availability: -