| Expression pattern: |
UP |
| Associated gene: |
tumor protein D52 (TPD52), NF-kappaB p65 |
| Associated microRNA: |
miR-495-3p |
| Biological function: |
promotes proliferation; promotes migration; promotes invasion; promotes EMT; promotes tumor growth/tumorigenesis |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-495-3p to upregulate TPD52 and activate the NF-kappaB signaling pathway. |
| Biological pathway or process: |
NF-kappaB (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circEZH2 expression was significantly associated with the TNM stage (p=0.0110). |
| Description: |
circEZH2 (hsa_circ_0006357) is up-regulated in LUAD tissues and cell lines and promotes proliferation, migration, invasion and EMT, enhancing xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-495-3p to upregulate TPD52, leading to activation of the NF-kappaB pathway. |
| Confidence score: |
0.8254 |