| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-20a-5p |
| Biological function: |
circ_0009910 promotes AML cell growth and proliferation, supports G1-S cell cycle progression, and inhibits apoptosis; knockdown of circ_0009910 inhibits AML cell proliferation and tumor growth and induces apoptosis. |
| Molecular mechanism: |
circ_0009910 functions as a sponge for miR-20a-5p; circ_0009910 knockdown increases miR-20a-5p expression, thereby suppressing AML cell growth. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); apoptosis (inhibits); cell cycle (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Microarray; RT-qPCR; FISH / smFISH; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0009910 expression predicted poor risk and worse outcome/prognosis in AML patients; circ_0009910 might serve as a novel outcome biomarker for AML. |
| Description: |
circ_0009910 is up-regulated in AML bone marrow samples and leukemia cell lines, and high expression is associated with poor-risk disease and shorter overall survival. Functionally, circ_0009910 promotes AML5 cell proliferation, cell cycle progression, and xenograft growth while suppressing apoptosis. Mechanistically, it acts through miR-20a-5p sponging/inhibition, and circ_0009910 knockdown increases miR-20a-5p to suppress AML cell growth. |
| Confidence score: |
0.8416 |