| Expression pattern: |
UP |
| Associated gene: |
Bcl-2 |
| Associated microRNA: |
miR-497 |
| Biological function: |
circPVT1 acts as an oncogene in NSCLC; knockdown inhibits NSCLC cell proliferation, induces apoptosis, and suppresses tumor growth. |
| Molecular mechanism: |
circPVT1 functions as a competing endogenous RNA for miR-497 and relieves miR-497-mediated inhibition of Bcl-2 expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; Survival Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
High circPVT1 expression is associated with aggressive clinicopathological characteristics and poor prognosis; circPVT1 may serve as a promising diagnostic biomarker and therapeutic target for NSCLC patients. |
| Description: |
circPVT1 is up-regulated in NSCLC tissues and cell lines, and high expression is associated with larger tumor size, advanced TNM stage, and shorter overall survival. Functionally, circPVT1 promotes NSCLC proliferation and tumor growth while inhibiting apoptosis through a ceRNA mechanism involving miR-497 and Bcl-2. |
| Confidence score: |
0.7396 |