| Expression pattern: |
UP |
| Associated gene: |
ADAM10, cyclin D1, MMP9, MMP2 |
| Associated microRNA: |
miR-515-5p |
| Biological function: |
circFOXM1 promotes prostate cancer cell proliferation, migration, invasion and tumor growth, and supports cell cycle progression; circFOXM1 silencing represses proliferation, migration and invasion and induces G0/G1 cell cycle arrest. |
| Molecular mechanism: |
circFOXM1 acts as a molecular sponge for miR-515-5p and regulates ADAM10 expression through the miR-515-5p/ADAM10 axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry); Cohort Study; Survival Analysis |
| Clinical significance: |
High circFOXM1 expression was associated with lymph-node metastasis, tumor stage, gleason score and lower overall survival; circFOXM1 may function as a promising therapeutic target for PCa. |
| Description: |
circFOXM1 is upregulated in prostate cancer tissues and cells and high expression predicts poorer overall survival. Functionally, circFOXM1 promotes PCa proliferation, migration, invasion, cell cycle progression and tumor growth. Mechanistically, it acts as a ceRNA sponge for miR-515-5p to regulate ADAM10 expression through the circFOXM1/miR-515-5p/ADAM10 axis. |
| Confidence score: |
0.7891 |