| Expression pattern: |
DS |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Associated with immune processes including leukocyte migration/chemotaxis and antigen processing and presentation via MHC class II; potentially promotes T-cell activation-related programs in OA cartilage. |
| Molecular mechanism: |
Coexpression and GSEA associations with immune-response gene sets related to antigen presentation via MHC class II and T-cell activation. |
| Biological pathway or process: |
immune regulation (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circPTK2-OA is a novel intronic circRNA differentially expressed in OA cartilage and is strongly associated (by coexpression/GSEA) with immune processes, particularly leukocyte chemotaxis and MHC class II antigen processing/presentation, suggesting a role in shaping adaptive immune activation in OA. |
| Confidence score: |
0.1768 |