| Expression pattern: |
DN |
| Associated gene: |
SOCS2, Ago2 |
| Associated microRNA: |
miR-1307-3p |
| Biological function: |
Inhibits gastric cancer cell proliferation, migration and invasion and promotes apoptosis; suppresses tumor growth in xenograft mice. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-1307-3p to upregulate SOCS2 expression (Ago2-associated). |
| Biological pathway or process: |
ceRNA regulation (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis; Transfection; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; H&E Staining; CCK8 |
| Clinical significance: |
- |
| Description: |
circDIDO1 is down-regulated in gastric cancer and functions as a tumor suppressor. Mechanistically, it sponges miR-1307-3p to upregulate SOCS2, thereby inhibiting proliferation/migration/invasion and promoting apoptosis. RGD-modified exosomes delivering circDIDO1 show anti-tumor efficacy in vitro and in a cell line-derived xenograft model. |
| Confidence score: |
0.7302 |