| Expression pattern: |
UP |
| Associated gene: |
CANX, IGF2BP1 |
| Associated microRNA: |
miR-505-3p |
| Biological function: |
promotes cholesterol synthesis, proliferation, migration and invasion, and inhibits apoptosis in prostate cancer cells; promotes tumor growth and metastasis in vivo |
| Molecular mechanism: |
m6A modification enhances circFAM126A transcript stability via IGF2BP1 binding; circFAM126A sponges miR-505-3p to upregulate CANX (ceRNA axis) |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); lipid metabolism (promotes); metastasis (promotes); angiogenesis (promotes); immune regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Bioinformatics Analysis; RNA-seq; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Back-Splice Junction PCR / divergent primers PCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; ROC Analysis; Survival Analysis; Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; MeRIP / MeRIP-seq; In Vivo Animal Model; IHC (Immunohistochemistry); Oil Red O Staining |
| Clinical significance: |
circFAM126A high expression was positively correlated with tumor size, TNM stage, and microvascular invasion; ROC AUC=0.8625 for distinguishing PCa tissue from normal tissue; higher circFAM126A expression had shorter overall survival |
| Description: |
circFAM126A (hsa_circ_0001971) is up-regulated in prostate cancer and promotes malignant phenotypes and cholesterol synthesis. Mechanistically, m6A/IGF2BP1 increases its RNA stability, and circFAM126A acts as a ceRNA by sponging miR-505-3p to increase CANX expression, enhancing tumor growth and metastasis. |
| Confidence score: |
0.8981 |