circRNA basic information
circBase ID: hsa_circ_0004315
Name: hsa_circ_GLG1
Synonym: -
Host Gene: GLG1
Genomic location(hg19): chr16:74491771-74493687:-
Genomic location(hg38): chr16:74457873-74459789:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissue; normal tissue; paracancerous tissue; normal solid tissue; primary tumor
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KIF20A, NCAPG, TTK, PLK4, CDC6
Associated microRNA: hsa-miR-195-5p, hsa-miR-214-3p, hsa-miR-424-5p
Biological function: May act as a ceRNA to downregulate miRNA expression and contribute to HCC development/progression.
Molecular mechanism: ceRNA mechanism (circRNA sponges miRNA to regulate hub gene expression).
Biological pathway or process:

ceRNA regulation (other); cell cycle (promotes); proliferation (promotes)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

May serve as a novel prognostic factor/marker for HCC patients.
Description:

hsa_circ_0004315 is identified as an upregulated DEC in HCC based on integrated GEO microarray analysis and is modeled as a ceRNA that sponges hsa-miR-195-5p/hsa-miR-214-3p/hsa-miR-424-5p, potentially increasing survival-related hub gene expression. The study proposes it as a prognostic factor, pending experimental validation.
Confidence score:

0.1768
Other information
Title:

Identification of potentially functional circular RNAs hsa_circ_0070934 and hsa_circ_0004315 as prognostic factors of hepatocellular carcinoma by integrated bioinformatics analysis.

Journal: Scientific reports
Published: 2022
PubMed ID: 35322101
Study type:

bioinformatics study
Data availability: GSE164803; GSE94508; GSE97332; TCGA-LIHC; 10.1038/s41598-022-08867-w
Code availability: -