circRNA basic information
circBase ID: hsa_circ_0001445
Name: hsa_circ_SMARCA5
Synonym: circSMARCA5
Host Gene: SMARCA5
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary prostate cancer tissues; metastatic prostate cancer tissues; benign prostate cancer tissues
Cell lines:

DU145; PC3; LNCaP; RWPE-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: TIMP3, Ago2, KAT5
Associated microRNA: miR-181b-5p, miR-17-3p
Biological function: Inhibits prostate cancer cell growth, migration, invasion, tumor growth and lung metastasis; acts as a tumor suppressor.
Molecular mechanism: circSMARCA5 acts as a miRNA sponge for miR-181b-5p and miR-17-3p to increase TIMP3 expression; KAT5 promotes circSMARCA5 biogenesis and thereby modulates the circSMARCA5/miRNA/TIMP3 axis.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Transfection; MTT; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

circSMARCA5 is down-regulated in prostate cancer tissues and cell lines and functions as a tumor suppressor. It inhibits proliferation, migration, invasion, and metastasis by sponging miR-181b-5p and miR-17-3p to relieve repression of TIMP3; KAT5 promotes circSMARCA5 biogenesis and impacts this axis.
Confidence score:

0.8166
Other information
Title:

A circular RNA, circSMARCA5, inhibits prostate cancer proliferative, migrative, and invasive capabilities via the miR-181b-5p/miR-17-3p-TIMP3 axis.

Journal: Aging
Published: 2021
PubMed ID: 34390329
Study type:

combined biological and clinical study
Data availability: -
Code availability: -