circRNA basic information
circBase ID: hsa_circ_0062389
Name: hsa_circ_PI4KA
Synonym: -
Host Gene: PI4KA
Genomic location(hg19): chr22:21158587-21159453:-
Genomic location(hg38): chr22:20804299-20805165:-
Subcellular localization: unclear
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues
Cell lines:

H1650; H23; H522; A549; H1703; H460; BEAS-2B; HEK-293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CCNE1
Associated microRNA: miR-103a-3p
Biological function: Promotes NSCLC cell proliferation and cell cycle progression; high expression is associated with advanced TNM stage and lymph-node metastasis.
Molecular mechanism: hsa_circ_0062389 functions as a ceRNA/miRNA sponge for miR-103a-3p to mediate CCNE1 expression in NSCLC.
Biological pathway or process:

proliferation (promotes); cell cycle (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Bioinformatics Analysis
Clinical significance:

High hsa_circ_0062389 expression was associated with advanced TNM stage, lymph-node metastasis and poor prognosis in NSCLC patients.
Description:

hsa_circ_0062389 is up-regulated in NSCLC tissues and cell lines and is associated with advanced TNM stage, lymph-node metastasis and poor prognosis. Functionally, it promotes NSCLC cell proliferation and cell cycle progression. Mechanistically, it acts as a sponge for miR-103a-3p to increase CCNE1 expression, forming the hsa_circ_0062389/miR-103a-3p/CCNE1 axis.
Confidence score:

0.7129
Other information
Title:

hsa_circ_0062389 promotes the progression of non-small cell lung cancer by sponging miR-103a-3p to mediate CCNE1 expression.

Journal: Cancer genetics
Published: 2020
PubMed ID: 31962276
Study type:

combined biological and clinical study
Data availability: The dataset supporting the conclusions of this article is included within the article; Supplementary material associated with this article can be found, in the online version, at doi: 10.1016/j.cancergen.2019.12. 004
Code availability: -