| Expression pattern: |
UP |
| Associated gene: |
PCNA |
| Associated microRNA: |
- |
| Biological function: |
promotes glioma cell proliferation, cell cycle progression, migration, invasion, metastasis, and tumorigenesis |
| Molecular mechanism: |
circ-SMAD7 promotes glioma progression by upregulating PCNA mRNA and protein expression |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); metastasis (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Cell Cycle Assay; Transwell Assay; Western Blot |
| Clinical significance: |
circ-SMAD7 expression was associated with patients' WHO stage and KPS score; circ-SMAD7/PCNA might be a novel therapeutic strategy in glioma |
| Description: |
circ-SMAD7 is up-regulated in glioma tissues and glioma cell lines. Functional knockdown experiments indicate that circ-SMAD7 promotes glioma cell proliferation, cell-cycle progression, migration, and invasion, likely through upregulating PCNA expression. Its expression is associated with WHO stage and KPS score, suggesting potential clinical relevance as a therapeutic target. |
| Confidence score: |
0.5414 |