circRNA basic information
circBase ID: hsa_circ_0008234
Name: hsa_circ_FOXP1
Synonym: hsa-FOXP1_0001
Host Gene: FOXP1
Genomic location(hg19): chr3:71090478-71102924:-
Genomic location(hg38): chr3:71041327-71053773:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0013209
MONDO name: metabolic dysfunction-associated steatotic liver disease
Disease details: metabolic-associated fatty liver disease / MAFLD
Disease DO ID:
 0080208
Disease MeSH ID:
 D065626
Disease NCIt ID:
 C84444
Disease ICD11 ID:
 1912806631
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

liver tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: IGF2BP1, IGF2BP2, IGF2BP3, HNRNPC, YTHDC1, YTHDF1
Associated microRNA: -
Biological function: -
Molecular mechanism: m6A modification level of hsa-FOXP1_0001 is altered in MAFLD liver tissues (increased m6A methylation).
Biological pathway or process:

m6A modification (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; MeRIP / MeRIP-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa-FOXP1_0001 (hsa_circ_0008234) is down-regulated in MAFLD liver tissues versus controls and was RT-qPCR-validated. Its m6A methylation level is increased in MAFLD, and it is predicted to bind m6A reader proteins, suggesting m6A-associated regulation in MAFLD; its direct mechanistic role in MAFLD was not functionally tested.
Confidence score:

0.5135
Other information
Title:

Expression profile and N6-methyadenosine modification of circular RNA analysis in MAFLD.

Journal: BMC gastroenterology
Published: 2025
PubMed ID: 40069595
Study type:

combined biological and clinical study
Data availability: 10.1186/s12876-025-03722-4
Code availability: -