circRNA basic information
circBase ID: hsa_circ_0000751
Name: -
Synonym: circ-0000751
Host Gene: -
Genomic location(hg19): chr17:27620262-27620746:-
Genomic location(hg38): chr17:29293244-29293728:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum exosomes; BCa tissues; nontumor breast tissues; paracancerous normal tissues
Cell lines:

MDA-MB-231; BT549; MCF-7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Up-regulated in serum exosomes from BCa patients and identified as one of three circRNAs differentially expressed in both datasets; no specific mechanistic function was further established.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
M
Validation methods:

RNase R Treatment; RT-qPCR; RNA-seq; Microarray; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

CircRNAs enriched in circulating exosomes may serve as biomarkers for BCa diagnosis, but no specific diagnostic or prognostic performance was reported for hsa-circRNA-00000751.
Description:

hsa-circRNA-00000751 was identified as differentially expressed in both serum exosome RNA-seq and breast tissue microarray datasets, and RT-qPCR showed it was up-regulated in serum exosomes from BCa patients. Unlike hsa-circRNA-0088088 and hsa-circRNA-0005795, it was not further characterized mechanistically in this study.
Confidence score:

0.5351
Other information
Title:

Identification of circRNA-miRNA networks for exploring an underlying prognosis strategy for breast cancer.

Journal: Epigenomics
Published: 2020
PubMed ID: 31920098
Study type:

combined biological and clinical study
Data availability: GSE101123; Supplementary Material 1; Supplementary Material 2; https://www.futuremedicine.com/d oi/suppl/10.2217/epi-2019-0058
Code availability: -