circRNA basic information
circBase ID: hsa_circ_0000285
Name: hsa_circ_HIPK3
Synonym: circRNA_000285
Host Gene: HIPK3
Genomic location(hg19): chr11:33362513-33363232:+
Genomic location(hg38): chr11:33340967-33341686:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer / BCa
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bladder cancer tissues; adjacent tissues; serum samples
Cell lines:

CCC-HB-2; HTB-9; T24; J82; SW780; RT4; RT4/DDP
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Downregulated in bladder cancer tissues, serum, and bladder cancer cell lines; lower expression is associated with cisplatin resistance and adverse clinicopathological features, suggesting a role as a diagnostic, prognostic, and chemotherapy-response biomarker.
Molecular mechanism: The molecular mechanism was not experimentally defined; the authors proposed that regulation of miR-124 and miR-558 may require further investigation.
Biological pathway or process:

chemoresistance (inhibits); drug resistance (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Survival Analysis
Clinical significance:

hsa_circ_0000285 may serve as a biomarker for bladder cancer diagnosis, chemotherapy response prediction, and prognosis; its serum level was an independent prognostic factor, and high expression was associated with longer overall survival.
Description:

hsa_circ_0000285, derived from the HIPK3 locus, is significantly downregulated in bladder cancer tissues, serum, and bladder cancer cell lines. Lower expression is associated with cisplatin resistance, larger and more advanced tumors, metastasis-related clinical features, and poorer overall survival, supporting its use as a diagnostic, prognostic, and chemotherapy-response biomarker.
Confidence score:

0.4187
Other information
Title:

Downregulation of hsa_circ_0000285 serves as a prognostic biomarker for bladder cancer and is involved in cisplatin resistance.

Journal: Neoplasma
Published: 2019
PubMed ID: 30509102
Study type:

combined biological and clinical study
Data availability: Supplementary Table 1; Supplementary Figure 1; Supplementary Figure 2
Code availability: -