| Expression pattern: |
UP |
| Associated gene: |
FOXP4, Ago2 |
| Associated microRNA: |
miR-138-5p |
| Biological function: |
High expression of circ-ZNF609 promotes renal carcinoma cell proliferation and invasion, while downregulation inhibits proliferation and invasion. |
| Molecular mechanism: |
circ-ZNF609 functions as a ceRNA and molecular sponge for miR-138-5p, thereby upregulating FOXP4 expression in renal carcinoma cells. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ-ZNF609 is up-regulated in renal carcinoma cell lines and promotes renal carcinoma cell proliferation and invasion. Mechanistically, it acts as a ceRNA by sponging miR-138-5p, thereby increasing FOXP4 expression through the circ-ZNF609/miR-138-5p/FOXP4 axis. |
| Confidence score: |
0.7328 |