circRNA basic information
circBase ID: hsa_circ_0076251
Name: hsa_circ_ZFAND3
Synonym: -
Host Gene: ZFAND3
Genomic location(hg19): chr6:38050167-38084515:+
Genomic location(hg38): chr6:38082391-38116739:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissue; adjacent nontumorous liver tissue; liver tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis
Clinical significance:

Potential diagnostic biomarker for HCC; independent prognostic marker in HCC (high expression associated with favorable survival).
Description:

hsa_circ_0076251 is significantly down-regulated in HCC tissues and decreases from CH to LC to HCC. It shows diagnostic value by ROC analysis and serves as an independent prognostic indicator, where higher expression is associated with more favorable survival in HCC patients.
Confidence score:

0.6813
Other information
Title:

Hsa_circ_0028502 and hsa_circ_0076251 are potential novel biomarkers for hepatocellular carcinoma.

Journal: Cancer medicine
Published: 2019
PubMed ID: 31595711
Study type:

combined biological and clinical study
Data availability: GSE94508
Code availability: -