circRNA basic information
circBase ID: hsa_circ_0001439
Name: -
Synonym: circ_0001439
Host Gene: -
Genomic location(hg19): chr4:129913321-129925031:-
Genomic location(hg38): chr4:128992166-129003876:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; plasma exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential biomarker for LUAD; predicted functional role through circRNA-miRNA-mRNA interactions
Molecular mechanism: Predicted circRNA-miRNA-mRNA interaction network and possible miRNA sponge mechanism
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNase R Treatment; Sanger Sequencing; RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential biomarker for LUAD
Description:

hsa_circ_0001439 was significantly upregulated in plasma exosomes from early-stage LUAD patients and validated by qRT-PCR, RNase R treatment, and Sanger sequencing. The study proposes it as a potential biomarker and predicts a circRNA-miRNA-mRNA regulatory network for its possible function.
Confidence score:

0.585
Other information
Title:

Circular RNAs expression profiles in plasma exosomes from early-stage lung adenocarcinoma and the potential biomarkers.

Journal: Journal of cellular biochemistry
Published: 2020
PubMed ID: 31646690
Study type:

combined bioinformatics and clinical study
Data availability: Supporting Information section; Table S1
Code availability: -