| Expression pattern: |
UP |
| Associated gene: |
FOXM1 |
| Associated microRNA: |
miR-455-3p |
| Biological function: |
circTADA2A promotes lung cancer cell proliferation, migration, invasion, aerobic glycolysis and tumor growth; propofol exerts antitumor effects partly by decreasing circTADA2A expression. |
| Molecular mechanism: |
circTADA2A functions as a miR-455-3p sponge and indirectly upregulates FOXM1 expression through binding miR-455-3p; propofol downregulates circTADA2A to suppress this circTADA2A/miR-455-3p/FOXM1 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (other); drug resistance (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; BrdU; Transwell Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
providing an effective clinical implication for propofol to prevent the development of lung cancer |
| Description: |
circTADA2A is up-regulated in lung cancer tissues and cell lines and acts as a pro-tumor circRNA. It sponges miR-455-3p to regulate FOXM1 expression, thereby promoting proliferation, migration, invasion and aerobic glycolysis. Propofol suppresses lung cancer progression by downregulating circTADA2A and inhibiting the circTADA2A/miR-455-3p/FOXM1 axis. |
| Confidence score: |
0.7177 |