circRNA basic information
circBase ID: hsa_circ_0007142
Name: -
Synonym: circ_007142 / circ_0007142
Host Gene: -
Genomic location(hg19): chr10:128768965-128788867:+
Genomic location(hg38): chr10:126970701-126990603:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for CRC
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Diagnostic biomarker in serum (ROC AUC 0.92)
Description:

circ_007142/circ_0007142 is up-regulated in CRC patient serum and can discriminate CRC from healthy controls (AUC 0.92).
Confidence score:

0.4187
Other information
Title:

Exosomal circ_0084043 derived from colorectal cancer-associated fibroblasts promotes in vitro endothelial cell angiogenesis by regulating the miR-140-3p/HIF-1alpha/VEGF signaling axis.

Journal: Heliyon
Published: 2024
PubMed ID: 38828320
Study type:

combined biological and clinical study
Data availability: Data supporting the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -