circRNA basic information
circBase ID: -
Name: hsa_circ_c17orf107
Synonym: hsa_circ _000224
Host Gene: c17orf107
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

sera; blood serum samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential noninvasive serum biomarker for HCC diagnosis; associated with tumor size and other clinical/laboratory factors.
Molecular mechanism: Bioinformatics-based selection suggested involvement of the selected circRNA panel in Wnt signalling, IKK/NF-kappaB signaling, and cell proliferation; no experimental molecular mechanism was validated for this circRNA.
Biological pathway or process:

Wnt/beta-catenin (other); NF-kappaB (other); proliferation (other)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Strong serum biomarker potential with relatively high sensitivity and specificity compared with AFP; associated with mean size of the tumor in the malignant group.
Description:

hsa_circ_000224 was selected as part of a bioinformatics-derived serum circRNA biomarker panel and validated by RT-qPCR. It was up-regulated in HCC serum, showed strong diagnostic performance compared with AFP, and its expression was associated with tumor size and relapse-free survival patterns.
Confidence score:

0.6023
Other information
Title:

circRNAs (hsa_circ_00156, hsa_circ _000224, and hsa_circ _000520) are novel potential biomarkers in hepatocellular carcinoma.

Journal: Journal of cellular biochemistry
Published: 2019
PubMed ID: 30426540
Study type:

combined bioinformatics and clinical study
Data availability: Supporting Information Table 1; Supporting Information Table 2; Supporting Information Table 3; Supporting Information Table 4
Code availability: -