| Expression pattern: |
UP |
| Associated gene: |
WNT1, TCF4, beta-catenin |
| Associated microRNA: |
- |
| Biological function: |
Promotes proliferation and migration of gastric cancer cells; upregulation indicates poor prognosis of GC patients. |
| Molecular mechanism: |
circHIPK3 promotes gastric cancer progression by activating/regulating the Wnt/beta-catenin pathway and increasing WNT1, TCF4 and beta-catenin levels. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Western Blot |
| Clinical significance: |
High circHIPK3 expression is negatively correlated with overall survival and indicates poor prognosis of GC patients. |
| Description: |
circHIPK3 is upregulated in gastric cancer tissues and cell lines, and high expression is associated with shorter overall survival. Functionally, circHIPK3 promotes proliferation and migration of GC cells, at least partly by activating the Wnt/beta-catenin pathway and regulating WNT1, TCF4 and beta-catenin. |
| Confidence score: |
0.6568 |