| Expression pattern: |
UP |
| Associated gene: |
GLS1, AGO2 |
| Associated microRNA: |
miR-214-3p |
| Biological function: |
Promotes proliferation, migration and invasion of CRC cells; promotes tumorigenesis in vivo; promotes glutamine metabolism (glutaminolysis). |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-214-3p to upregulate GLS1, thereby promoting glutamine metabolism. |
| Biological pathway or process: |
glutaminolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Clinical Sample Validation; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
High circCOL1A1 expression is associated with TNM stage, lymph node metastases, distant metastases, invasion, and worse overall survival in CRC patients. |
| Description: |
circCOL1A1 is up-regulated in CRC tissues and cell lines and promotes CRC cell proliferation, migration, invasion, EMT-like changes, tumorigenesis, and glutamine metabolism. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-214-3p, thereby increasing GLS1 and enhancing glutaminolysis. High circCOL1A1 expression is associated with advanced clinicopathologic features and poor overall survival. |
| Confidence score: |
0.8226 |