circRNA basic information
circBase ID: mmu_circ_0000807
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Mouse
Species details: Mus musculus
Tissue specimen:

colonic tissues; colorectal tissues; tumor tissues; serum; liver tissues
Cell lines:

-
In vivo animal model:

genetically engineered animal model; other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Promotes CRC development/tumorigenesis under hypoxia in mouse models.
Molecular mechanism: Hypoxia upregulates mmu_circ_0000807; in vivo knockdown reduces its expression and is used to assess its role in CRC development.
Biological pathway or process:

proliferation (promotes)
Detected method:
Q
H
Validation methods:

RT-qPCR; ISH (In Situ Hybridization); Transfection; In Vivo Animal Model; H&E Staining; Survival Analysis
Clinical significance:

-
Description:

In mouse CRC models (AOM-DSS and APCMin/+), hypoxia increases mmu_circ_0000807 expression in tumor-related tissues and serum. mmu_circ_0000807 is implicated in promoting CRC development/tumorigenesis under hypoxic conditions, supported by knockdown experiments in vivo.
Confidence score:

0.5619
Other information
Title:

Hypoxia-induced hsa_circ_0000826 is linked to liver metastasis of colorectal cancer.

Journal: Journal of clinical laboratory analysis
Published: 2020
PubMed ID: 32633429
Study type:

biological research
Data availability: -
Code availability: -