circRNA basic information
circBase ID: hsa_circ_0006168
Name: hsa_circ_CNOT6L
Synonym: hsa_circRNA_103670
Host Gene: CNOT6L
Genomic location(hg19): chr4:78694234-78697546:-
Genomic location(hg38): chr4:77773080-77776392:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005277
MONDO name: migraine disorder
Disease details: Migraine
Disease DO ID:
 6364
Disease MeSH ID:
 D008881
Disease NCIt ID:
 C89715
Disease ICD11 ID:
 669367341
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: Hsa-miR-570-5p, Hsa-miR-592, Hsa-miR-542-3p, Hsa-miR-628-5p, Hsa-miR-148b-5p
Biological function: unknown
Molecular mechanism: Predicted ceRNA network (circRNA-miRNA-mRNA); potential miRNA sponge activity (predicted).
Biological pathway or process:

PI3K/AKT (other); inflammation (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circRNA_103670 (hsa_circ_0006168) is up-regulated in migraine patient plasma and was validated by qRT-PCR. Bioinformatic predictions place it in a circRNA-miRNA-mRNA (ceRNA) network and suggest a possible link to PI3K/AKT-related inflammatory processes in migraine, but no direct functional experiments were performed.
Confidence score:

0.5135
Other information
Title:

Differential Expression and Bioinformatic Analysis of the circRNA Expression in Migraine Patients.

Journal: BioMed research international
Published: 2020
PubMed ID: 33178826
Study type:

combined biological and clinical study
Data availability: All data generated or analyzed during this study are included in this article.
Code availability: -